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- Title
Relation Between Left Atrial Wall Thickness in Patients with Atrial Fibrillation and Intracardiac Electrogram Characteristics and ATP-Provoked Dormant Pulmonary Vein Conduction.
- Authors
TAKAHASHI, KEIKO; OKUMURA, YASUO; WATANABE, ICHIRO; NAGASHIMA, KOICHI; SONODA, KAZUMASA; SASAKI, NAOKO; KOGAWA, RIKITAKE; ISO, KAZUKI; OHKUBO, KIMIE; NAKAI, TOSHIKO; HIRAYAMA, ATSUSHI
- Abstract
LA Wall Thickness, LA Electrogram, and Dormant PV Conduction Introduction Atrial remodeling plays a key role in development of the substrate for atrial fibrillation (AF). Whether the wall thicknesses of the left atrium (LA) and pulmonary vein (PV)-LA junction affect remodeling and AF ablation is unknown. We investigated the relationship between wall thicknesses, electrogram characteristics, and adenosine triphosphate (ATP)-provoked dormant PV conduction as they pertain to AF. Methods In 50 patients with AF and 25 patients without AF, wall thicknesses of the LA and PV-LA junction were measured on 320-slice computed tomography images. For the AF patients, NavX-based voltage maps generated during sinus rhythm were obtained, and ATP-provoked dormant PV conduction after PV isolation was evaluated. Results Walls of the LA and PV-LA junction were significantly thicker in the AF patients than in the control patients (1.83 ± 0.29 mm vs. 1.59 ± 0.28 mm, respectively; P = 0.0010; and 0.88 ± 0.14 mm vs. 0.65 ± 0.11 mm, P<0.0001, respectively). Wall thickness at the PV-LA junction was independently associated with AF (β = 0.40, P = 0.0002). In AF patients, the walls of the PV-LA junction showed stepwise thickening across bipolar voltages indicative of severe (bipolar voltage <33rd percentile) to moderate (33rd-66th percentiles) to mild fibrosis/scarring (≥66th percentile). Walls of the PV-LA junction with dormant PV conduction were significantly thicker than those without it (0.94 ± 0.19 mm vs. 0.86 ± 0.21 mm, respectively; P = 0.0025). Conclusions Together, the association between thickened PV-LA junction walls and AF and the increased bipolar voltage suggests that such wall thickening increases PV electrical activities, leading to initiation and maintenance of AF and perhaps to ATP-provoked dormant PV conduction.
- Subjects
JAPAN; ATRIAL fibrillation treatment; ACADEMIC medical centers; ADENOSINE triphosphate; ANALYSIS of variance; ATRIAL fibrillation; CATHETER ablation; CHI-squared test; COMPUTED tomography; STATISTICAL correlation; ELECTROPHYSIOLOGY; FISHER exact test; HEART conduction system; PULMONARY veins; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; DATA analysis software; DESCRIPTIVE statistics; LEFT heart atrium
- Publication
Journal of Cardiovascular Electrophysiology, 2015, Vol 26, Issue 6, p597
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1111/jce.12660