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- Title
Copper/Photoredox dual Catalyzed Syntheses of Allenenitriles via 1,5‐HAT.
- Authors
Li, Yuan‐Bo; Bi, Yu‐Xiang; Ke, Wen‐Chang; Wang, Cheng‐Yu; Hu, Duo‐Duo; Li, Yan; Wang, Xi‐Sheng
- Abstract
The first example of merging photoredox catalysis and copper catalysis for 1,4‐difunctionalization of 1,3‐enynes via 1,5‐HAT (hydrogen atom transfer) has been developed. The synthetic strategy exploits a radical translocation from an oxygen‐centered to a carbon‐centered radical with a subsequent radical addition to the 1,3‐enynes, affording tetrasubstituted allenenitriles in up to 90% yield. This strategy has mild reaction conditions, broad substrate scope and excellent functional group tolerance.
- Subjects
ABSTRACTION reactions; RADICALS (Chemistry); FUNCTIONAL groups; COPPER
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 6, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300234