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- Title
Description of an adenovirus A31 outbreak in a paediatric haematology unit.
- Authors
Leruez-Ville, M.; Chardin-Ouachée, M.; Neven, B.; Picard, C.; Le Guinche, I.; Fischer, A.; Rouzioux, C.; Blanche, S.
- Abstract
Adenovirus infections result in significant morbidity and mortality in allogeneic haematopoietic stem cell transplanted (hSCT) children. Adenovirus from species C and B account for more than 90% of adenoviruses recovered after hSCT. However, infections due to adenovirus A31 have been increasingly reported in recent years. Between April 2002 and April 2005, blood samples obtained every 2 weeks from 58 hSCT children were screened for adenovirus species A to C by quantitative real-time PCR. Phylogenetic analysis was realized after amplification and sequencing of the entire hexon gene. Fifteen cases of adenovirus infection with viraemia were recovered during this 3 years period. During spring/summer 2003, seven cases occurred and were due to an adenovirus species A. Phylogenetic analysis of the seven strains showed that they belonged to the A31 genotype and shared 100% homology. Clinical features of the seven HSCT children with A31 adenovirus viraemia are described. We describe here an epidemic spread of adenovirus genotype A31 in a paediatric haematology unit. Timing, location and hexon gene genotyping results highly suggested a nosocomial origin to this epidemic. The burden of adenovirus A31 infection needs to be further assessed in this context.Bone Marrow Transplantation (2006) 38, 23–28. doi:10.1038/sj.bmt.1705389; published online 15 May 2006
- Subjects
ADENOVIRUS diseases; STEM cell transplantation; HEMATOPOIETIC stem cells; PEDIATRIC hematology; HEMATOPOIETIC system; EPIDEMIOLOGY; GENETIC polymorphisms
- Publication
Bone Marrow Transplantation, 2006, Vol 38, Issue 1, p23
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705389