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- Title
The prevalence of vitamin A deficiency and its public health significance in children in low- and middle-income countries: A systematic review and modelling analysis.
- Authors
Peige Song; Adeloye, Davies; Shuting Li; Dong Zhao; Xinxin Ye; Qing Pan; Yiwen Qiu; Ronghua Zhang; Rudan, Igor
- Abstract
Background Vitamin A deficiency (VAD) is widely recognised as a major public health concern in low- and middle-income countries (LMICs). Despite various interventions implemented in many countries, a lack of reliable data is hindering progress. We aimed to consolidate available data and quantify estimates of the prevalence of VAD among children ≥18 years in LMICs. Methods We searched PubMed, Medline and Embase for studies reported the prevalence of VAD or marginal (m)VAD among children. A multilevel mixed-effects meta-regression approach was applied to establish the regression models for VAD and mVAD prevalence. The total numbers of children affected by VAD and mVAD in LMICs in 2019 were separately calculated from the estimated age- and socio-demographic index (SDI)-specific prevalence with their corresponding United Nations Population Division populations projections. We estimated areas of significant public health concern in 165 LMICs using the lower confidence interval (CI) of VAD prevalence. Results A total of 116 articles from 40 LMICs were retained. In 2019, VAD and mVAD affected 333.95 million (95% CI=253.00-433.74) and 556.13 million (95% CI=388.83-767.94) children and adolescents in 165 LMICs, respectively, corresponding to a prevalence of 14.73% (95% CI=11.16-19.14) and 24.54% (95% CI=17.15-33.88). The prevalence of both VAD and mVAD was the highest in children aged 0-5 years at 19.53% (95% CI=15.03-24.91) and 28.22% (95% CI=20.00-38.24), respectively, with both steadily decreasing to 10.09% (95% CI=7.44-13.50) and 20.76% (95% CI=14.16-29.50) in adolescents aged 13-18 years. The prevalence of VAD was significantly higher in the low SDI region at 29.67% (95% CI=22.67-37.53) compared to 5.17% (95% CI=3.14-8.43) estimated in the high-middle SDI region. 68 of the 165 LMICs (41.21%) were classified as areas of moderate to severe VAD public health significance. Conclusions VAD continues to pose a significant public health concern in many low-income settings. Development in LMICs is a crucial factor for VAD, with a disproportionately higher burden in low SDI regions.
- Subjects
ONLINE information services; MIDDLE-income countries; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; GLOBAL burden of disease; SYSTEMATIC reviews; PUBLIC health; VITAMIN A deficiency; COMPARATIVE studies; LOW-income countries; DISEASE prevalence; DESCRIPTIVE statistics; MEDLINE; SOCIODEMOGRAPHIC factors; CHILDREN
- Publication
Journal of Global Health, 2023, Vol 13, p1
- ISSN
2047-2978
- Publication type
Article
- DOI
10.7189/jogh.13.04084