We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation.
- Authors
He, Wei; Xu, Jinzhi; Mu, Ruoyu; Li, Qiu; Lv, Da-lun; Huang, Zhen; Zhang, Junfeng; Wang, Chunming; Dong, Lei
- Abstract
High-salt diets are associated with an elevated risk of autoimmune diseases, and immune dysregulation plays a key role in cancer development. However, the correlation between high-salt diets (HSD) and cancer development remains unclear. Here, we report that HSD increases the local concentration of sodium chloride in tumour tissue, inducing high osmotic stress that decreases both the production of cytokines required for myeloid-derived suppressor cells (MDSCs) expansion and MDSCs accumulation in the blood, spleen, and tumour. Consequently, the two major types of MDSCs change their phenotypes: monocytic-MDSCs differentiate into antitumour macrophages, and granulocytic-MDSCs adopt pro-inflammatory functions, thereby reactivating the antitumour actions of T cells. In addition, the expression of p38 mitogen-activated protein kinase-dependent nuclear factor of activated T cells 5 is enhanced in HSD-induced M-MDSC differentiation. Collectively, our study indicates that high-salt intake inhibits tumour growth in mice by activating antitumour immune surveillance through modulating the activities of MDSCs. High-salt intake can promote pro-inflammatory responses associated with pathological conditions. However, here, the authors show that high-salt diet may have an antitumor protective role by modulating the accumulation and phenotype of myeloid derived suppressor cells and enhancing immunosurveillance.
- Subjects
MYELOID-derived suppressor cells; HIGH-salt diet; CELL differentiation; OSMOTIC pressure; T cells; TUMORS; HEMATOPOIESIS; MACROPHAGES
- Publication
Nature Communications, 2020, Vol 11, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-15524-1