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- Title
A randomized Phase III trial of lobe-specific vs. systematic nodal dissection for clinical Stage I-II non-small cell lung cancer (JCOG1413).
- Authors
Tomoyuki Hishida; Hisashi Saji; Shun-ichi Watanabe; Hisao Asamura; Keiju Aokage; Tomonori Mizutani; Masashi Wakabayashi; Taro Shibata; Morihito Okada
- Abstract
In January 2017, the Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group commenced a randomized Phase III trial to confirm the clinical benefit of lobe-specific nodal dissection for clinical Stage I-II non-small cell lung cancer. The primary endpoint is overall survival, and the main objective is to confirm the non-inferiority of lobe-specific in comparison to systematic nodal dissection with regard to lobectomy. The secondary endpoints are relapse-free survival, %local recurrence, %regional lymph node recurrence, operation time, blood loss, length of hospitalization, duration of chest tube placement and adverse events. A total of 1700 patients will be accrued from 44 Japanese institutions within 5 years. This study is the first and large prospective trial to evaluate whether the difference in the area of nodal dissection affects the overall survival of patients with relatively early-stage non-small cell lung cancer. This trial has been registered in the UMIN Clinical Trials Registry as UMIN000025530.
- Publication
Japanese Journal of Clinical Oncology, 2018, Vol 48, Issue 2, p190
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyx170