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- Title
Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19.
- Authors
Duployez, Nicolas; Demonchy, Jordane; Berthon, Céline; Goutay, Julien; Caplan, Morgan; Moreau, Anne-Sophie; Bignon, Anne; Marceau-Renaut, Alice; Garrigue, Delphine; Raczkiewicz, Imelda; Geffroy, Sandrine; Bucci, Maxime; Alidjinou, Kazali; Demaret, Julie; Labalette, Myriam; Brousseau, Thierry; Dupont, Annabelle; Rauch, Antoine; Poissy, Julien; Susen, Sophie
- Abstract
Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60–70 years, 70–80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings.
- Subjects
AGE distribution; C-reactive protein; CARRIER proteins; CYTOKINES; HEMATOPOIESIS; HOSPITAL care; LONGITUDINAL method; NEUTROPHILS; RISK assessment; RETROSPECTIVE studies; SEVERITY of illness index; NUCLEAR proteins; DESCRIPTIVE statistics; LEUKOCYTE count; SEQUENCE analysis; COVID-19
- Publication
Cancers, 2020, Vol 12, Issue 7, p1992
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers12071992