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- Title
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL).
- Authors
Werner, Michael T.; Qian Zhang; Wasik, Mariusz A.
- Abstract
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.
- Subjects
CELL differentiation; TRANSFERASES; T-cell lymphoma; INDIVIDUALIZED medicine; SYMPTOMS
- Publication
Cancers, 2017, Vol 9, Issue 10, p138
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers9100138