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- Title
The Use of Radioprotective Agents to Prevent Effects Associated with Aging.
- Authors
Bykov, V. N.; Grebenyuk, A. N.; Ushakov, I. B.
- Abstract
Anti-aging properties can be found in many compounds with radiation-protective effects. Such compounds include the following: bioflavonoids, some antioxidants (N-acetylcysteine), melatonin, some non-steroid anti-inflammatory agents and statins, angiotensin converting enzyme inhibitors, metformin, rapamycin, etc. The effects of the drugs can develop both in the case of their long-term use and in case of a single application against the background of acute exposure to ionizing radiation at lethal doses. At the same time, "classical" radiation-protective agents such as cystamine, amifostine, adrenergic alfa-blockers, and androgenic drugs were not revealed to have geroprotective properties, which may be due to their high toxicity.
- Subjects
RADIATION-protective agents; ANTI-inflammatory agents; ACE inhibitors; NONSTEROIDAL anti-inflammatory agents; PHARMACOLOGY; IONIZING radiation
- Publication
Biology Bulletin, 2019, Vol 46, Issue 12, p1657
- ISSN
1062-3590
- Publication type
Article
- DOI
10.1134/S1062359019120021