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- Title
Adenovirus 4/7 Vaccine's Effect on Disease Rates Is Associated With Disappearance of Adenovirus on Building Surfaces at a Military Recruit Base.
- Authors
Broderick, Michael; Balansay, Melinda; Vo, Scott; Myers, Christopher; Osuna, Angel; Russell, Kevin
- Abstract
<bold>Background: </bold>Febrile respiratory illness resulting from adenovirus types 4 and 7 (Ad4/7) was endemic at military training camps, but controlled by an Ad4/7 vaccine from the 1970s to 1999, the year it was discontinued. Thereafter, rates returned to prevaccine levels. Rates dropped after reintroduction of an Ad4/7 vaccine in 2011.<bold>Methods: </bold>Surfaces of the barracks and medical clinic of a training camp were swabbed in 3 studies in 2004 and 1 study in 2007, and tested with culture and polymerase chain reaction (PCR). Similar swabbing was done in 2013 and 2015 and tested with PCR.<bold>Findings: </bold>In the studies before 2011 (prevaccine), 12% of samples were Ad4/7 positive by culture and 27% positive by PCR. In the 2 studies after 2011 (postvaccine), no samples were Ad4/7 positive.<bold>Discussion/impact/recommendations: </bold>The Ad 4/7 vaccine has resulted in the near elimination of Ad4/7-related disease and the disappearance of Ad4/7 from surfaces in a military basic training camp. Renewed transmission of Ad4/7 in this setting would likely require new importation from military recruits and an immunologically naive cohort, which the current vaccination program prevents.
- Subjects
CALIFORNIA; RECRUITING &; enlistment (Armed Forces); MILITARY training camps; ADENOVIRUSES; RESPIRATORY disease diagnosis; POLYMERASE chain reaction; THERAPEUTICS; PREVENTION of epidemics; EDUCATION of military personnel; PREVENTION of communicable diseases; EDUCATION; EPIDEMICS; HEALTH facility design &; construction; RESPIRATORY infections; MILITARY personnel; VIRUSES; DNA virus diseases; VIRAL vaccines; PHARMACODYNAMICS; STANDARDS; VACCINES
- Publication
Military Medicine, 2017, Vol 182, Issue 11, pe2069
- ISSN
0026-4075
- Publication type
journal article
- DOI
10.7205/MILMED-D-17-00109