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- Title
Prothrombotic and Inflammatory Effects of Intravenous Administration of Human Immunoglobulin G in Dogs.
- Authors
Tsuchiya, R.; Akutsu, Y.; Ikegami, A.; Scott, M. A.; Neo, S.; Ishikawa, T.; Hisasue, M.; Yamada, T.
- Abstract
Background: Intravenous administration of human immunoglobulin G (hIVIgG) has been suggested to potentiate thromboembolism in dogs, but supportive scientific reports are lacking. Objectives: To determine if hIVIgG therapy promotes hypercoagulability and inflammation in dogs. Animals: Twelve healthy Beagle dogs. Methods: Prospective, experimental trial. An hIVIgG/saline solution was infused IV at 1 g/kg BW over 8 hours to 6 dogs, and physiological saline was infused to the other 6 dogs. Blood samples were drawn before, during, and after infusion for serial measurement of indicators of coagulation and inflammation. Data were analyzed by 2-way repeated measures analysis of variance. Results: Dogs administered hIVIgG developed mildly decreased blood platelet concentrations without thrombocytopenia (median, 200 × 103/μL; range, 150–302 × 103/μL; P < .01), leukopenia (median, 3.5 × 103/μL; range, 20–62 × 103/μL; P < .001), and mildly increased plasma total protein concentrations (median, 6.3 g/dL; range, 5.6–6.7 g/dL; P < .001). Administration of hIVIgG was also associated with increases in fibrin/fibrinogen degradation products in all dogs (either 5 μg/mL or 10 μg/dL), thrombin-antithrombin III complexes (median, 7.2 ng/mL; range, 4.9–14.2 ng/mL; P < .001), and C-reactive protein concentrations (median, 2.5 mg/dL; range, 0.5–4.3 mg/dL; P < .01). Conclusion and Clinical Importance: Administration of hIVIgG to dogs promotes hypercoagulability and an inflammatory state. This should be further evaluated and considered when using hIVIgG in dogs with IMHA or other prothrombotic conditions.
- Subjects
IMMUNOGLOBULIN G; THROMBOEMBOLISM; DOG diseases; THROMBOCYTOPENIA; BLOOD coagulation; INFLAMMATION
- Publication
Journal of Veterinary Internal Medicine, 2009, Vol 23, Issue 6, p1164
- ISSN
0891-6640
- Publication type
Article
- DOI
10.1111/j.1939-1676.2009.0402.x