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- Title
Cytokeratin19 positive hepatocellular carcinoma is associated with increased peritumoral ductular reaction.
- Authors
Xiaobo Cai; Li Feng; Heng Liu; Mingyi Xu; Yin Qu; Xinjian Wan; Chunfang Gao; Lungen Lu
- Abstract
Background and aims. Cytokeratin19 positive (CK19+) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19+ and CK19 negative (CK19-) HCC patients remains unclear. Material and methods. One hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables were collected, and immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin- 6 (IL-6) and β-catenin were performed in tumor and peritumor liver tissues. Results. CK19+ HCC patients had higher grade of peritumoral DR and proportion of proliferative DR than the CK19- group. The mean number or the proportion of cytoplasmic β-catenin+ DR was higher in the CK19+ group than in the CK19- group. Furthermore, there were more patients with nuclear β-catenin+ peritumoral DR in the CK19+ group as compared to the CK19- group. Conclusion. Peritumoral DR was more abundant and proliferative in CK19+ HCC patients, with higher level of nuclear translocation of β-catenin. However, it is unclear whether peritumoral DR is the cause or result of poor prognosis in these patients.
- Subjects
LIVER cancer patients; PROGENITOR cells; LIVER; IMMUNOHISTOCHEMISTRY; PROLIFERATING cell nuclear antigen; LIVER tumors
- Publication
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology, 2016, Vol 15, Issue 3, p386
- ISSN
1665-2681
- Publication type
Article
- DOI
10.5604/16652681.1198813