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- Title
PLCG1 Gene Mutations in Cutaneous T-Cell Lymphomas Revisited.
- Authors
Tensen, Cornelis P
- Abstract
The observation that mutations in the phospholipase C gamma 1 (PLCG1) gene (among which p.S345F was shown to be activating) are frequent (20%) in tumoral cutaneous T-cell lymphoma (CTCL) samples raised the possibility of targeting therapies against the PLCG1 signaling pathway. However, new data by Caumont et al. in this issue of JID show that PLCG1 mutations are far less prevalent than expected in CTCLs, which tempers the initial enthusiasm. This new study finds that only 3-5% of the CTCL tumor genomes (mycosis fungoides and Sézary syndrome) harbor PLCG1 mutations.
- Subjects
PHOSPHOLIPASE C; GENETIC mutation; CUTANEOUS T-cell lymphoma; CANCER invasiveness; SKIN disease genetics; GENETICS
- Publication
Journal of Investigative Dermatology, 2015, Vol 135, Issue 9, p2153
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2015.221