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- Title
Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.
- Authors
Syed, T. A.; Qureshi, Z. A.; Ali, S. M.; Ahmad, S; Ahmad, S. A.
- Abstract
The prevalence of onychomycosis, a superficial fungal infection that destroys the entire nail unit, is rising, with no satisfactory cure. The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil incorporated in a cream to manage toenail onychomycosis in a cohort. Sixty outpatients (39 M, 21 F) aged 18-80 years (mean 29.6) with 6-36 months duration of disease were randomized to two groups (40 and 20), active and placebo. After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group. Four patients in the active treatment group experienced subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurred in cured patients and no improvement was seen in medication-resistant and placebo participants.
- Subjects
ONYCHOMYCOSIS; TOENAILS; ANTIFUNGAL agents; TEA tree oil; DRUG tolerance; DRUG efficacy; DISEASES; THERAPEUTICS
- Publication
Tropical Medicine & International Health, 1999, Vol 4, Issue 4, p284
- ISSN
1360-2276
- Publication type
journal article
- DOI
10.1046/j.1365-3156.1999.00396.x