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- Title
Association of early life factors and acute lymphoblastic leukaemia in childhood: historical cohort study.
- Authors
Murray, L.; McCarron, P.; Bailie, K.; Middleton, R.; Smith, G. Davey; Dempsey, S.; McCarthy, A.; Gavin, A.; Davey Smith, G
- Abstract
In a historical cohort study of all singleton live births in Northern Ireland from 1971-86 (n=434,933) associations between early life factors and childhood acute lymphoblastic leukaemia were investigated. Multivariable analyses showed a positive association between high paternal age (> or =35 years) and acute lymphoblastic leukaemia (relative risk=1.49; 95% confidence interval (CI)=0.96--2.31) but no association with maternal age. High birth weight (> or =3500 g) was positively associated with acute lymphoblastic leukaemia (relative risk=1.66; 95% CI=1.18--2.33). Children of mothers with a previous miscarriage or increased gestation (> or =40 weeks) had reduced risks of ALL (respective relative risks=0.49; 95% CI=0.29--0.80, and 0.67; 95% CI=0.48--0.94). Children born into more crowded households (> or =1 person per room) had substantially lower risks than children born into less crowded homes with also some evidence of a lower risk for children born into homes with three adults (relative risks=0.56; 95% CI=0.35-0.91 and 0.58; 95% CI=0.21-1.61 respectively). These findings indicate that several early life factors, including living conditions in childhood and maternal miscarriage history, influence risk of acute lymphoblastic leukaemia in childhood.
- Subjects
LYMPHOBLASTIC leukemia in children; CHILDREN'S health
- Publication
British Journal of Cancer, 2002, Vol 86, Issue 3, p356
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6600012