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- Title
Acute Respiratory Distress Syndrome: Bench‐to‐Bedside Approaches to Improve Drug Development.
- Authors
Hussain, Musaddique; Xu, Chengyun; Ahmad, Mashaal; Wu, Ximei; Majeed, Abdul; Lu, Meiping; Wu, Xiling; Tang, Lanfang
- Abstract
Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the “omics” approaches, reevaluate the suitable therapeutic targets, resolve the problems of inadequate animal modeling, develop the strategies to reduce the heterogeneity, and reconsider new therapeutic and analytical approaches for better designs of clinical trials.
- Subjects
ADULT respiratory distress syndrome; DRUG development; HETEROGENEITY; ANIMAL models in research; CLINICAL trials
- Publication
Clinical Pharmacology & Therapeutics, 2018, Vol 104, Issue 3, p484
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.1034