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- Title
Detoxification and anticarcinogenic effects of Fucoidan in human hepatoblastoma and rat glioma cells.
- Authors
Joomin Lee; Hea Young Oh; Daejoong Kwon; Sun Yoon
- Abstract
Algal fucoidan, which is extracted from brown algae, is a marine sulfated polysaccharide that is endowed with important biological activities including anti-angiogenic and anti-tumoral effects. However, the mechanism by which fucoidan inhibits carcinogenesis is not known. Present study was attempted to evaluate detoxification and anticarcinogenic effects of fucoidan in human HepG2 hepatoblastoma and rat C6 glioma cells, respectively. 7-ethoxyresorufin O-deethylase (EROD) activity in TCDD(2,3,7,8-Tetrachlorodibenzo-p-dioxin)induced hepatoblastoma cell and hepatic S9-fraction decreased by fucoidan treatment in a concentration dependent manner. Proliferation of glioma cells was also inhibited by fucoidan in a dose-dependent manner determined by MTS. We further evaluated that the effect of fucoidan on 7-methoxyresorufin O-deethylase(MROD), cytochrom C phase II enzyme. These results suggest that fucoidan may exert detoxification and anticarcinogenic effects in human hepatoblastoma and neuronal cells, respectively. Related mechanisms involved with detoxification and anticarcinogenic effects of fucoidan were further studied.
- Subjects
DETOXIFICATION (Alternative medicine); POLYSACCHARIDES; ANTINEOPLASTIC agents; BROWN algae; CELL proliferation
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1095
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a1095-d