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- Title
Discovery of a potent nanoparticle P-selectin antagonist with anti-inflammatory effects in allergic airway disease.
- Authors
John, Alison E.; Lukacs, Nicholas W.; Berlin, Aaron A.; Palecanda, Aiyappa; Bargatze, Robert F.; Stoolman, Lloyd M.; Nagy, Jon O.
- Abstract
Identifies the novel P-selectin antagonists that would inhibit leukocyte attachment and rolling in vitro, and have potent anti-inflammatory effects in vivo in a murine model of allergic airway disease. Efficacy of formulation changes; Administration of polymerized lipid nanoparticle (PLNP) after establishing the leukocyte and selectin rolling interaction; Inhibition of peribronchial eosinophil recruitment by selectin PLNP.
- Subjects
SELECTINS; CELL adhesion molecules; LEUCOCYTES; NANOPARTICLES; EOSINOPHILS
- Publication
FASEB Journal, 2003, Vol 17, Issue 15, p2296
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.03-0166fje