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- Title
Salivary epidermal growth factor correlates with hospitalization length in rotavirus infection.
- Authors
Gómez-Rial, J.; Curras-Tuala, M. J.; Talavero-González, C.; Rodríguez-Tenreiro, C.; Vilanova-Trillo, L.; Gómez-Carballa, A.; Rivero-Calle, I.; Justicia-Grande, A.; Pardo-Seco, J.; Redondo-Collazo, L.; Salas, A.; Martinón-Torres, F.
- Abstract
<bold>Background: </bold>The IFI27 interferon gene expression has been found to be largely increased in rotavirus (RV)-infected patients. IFI27 gene encodes for a protein of unknown function, very recently linked to epidermal proliferation and related to the epidermal growth factor (EGF) protein. The EGF is a low-molecular-weight polypeptide that is mainly produced by submandibular and parotid glands, and it plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. Our aim was to determine salivary EGF levels in RV-infected patients in order to establish its potential relationship with IFI27 increased expression and EGF-mediated mucosal protection in RV infection.<bold>Methods: </bold>We conducted a prospective comparative study using saliva samples from 27 infants infected with RV (sampled at recruitment during hospital admission and at convalescence, i.e. at least 3 months after recovery) and from 36 healthy control children.<bold>Results: </bold>Median (SD) EGF salivary concentration was 777 (529) pg/ml in RV-infected group at acute phase and 356 (242) pg/m at convalescence, while it was 337 (119) pg/ml in the healthy control group. A significant association was found between EGF levels and hospitalization length of stay (P-value = 0.022; r2 = -0.63).<bold>Conclusions: </bold>The salivary levels of EGF are significantly increased during the acute phase of natural RV infection, and relate to length of hospitalization. Further assessment of this non-invasive biomarker in RV disease is warranted.
- Subjects
SALIVARY gland physiology; EPIDERMAL growth factor; LENGTH of stay in hospitals; ROTAVIRUS diseases; INTERFERON genetics; INTERFERON alpha; BIOMARKERS
- Publication
BMC Infectious Diseases, 2017, Vol 17, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-017-2463-0