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- Title
Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer.
- Authors
Lu Zheng; Da Li; Yi-Ming Zhou; Hui Yang; Di Cheng; Xiao-Xin Ma; Zheng, Lu; Li, Da; Zhou, Yi-Ming; Yang, Hui; Cheng, Di; Ma, Xiao-Xin
- Abstract
<bold>Background: </bold>The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown.<bold>Methods: </bold>RAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well-differentiated endometrial cancer tissue, and 35 cases of poorly-differentiated endometrial cancer tissue. Regression analysis was used to examine the relationship between RAGE and microvessel density. The knockdown of RAGE was achieved using a small interfering RNA in HEC-1A endometrial cancer cells. A xenografted tumour model was used to evaluate RAGE-mediated microvascular formation and proliferation of endometrial cancer cells.<bold>Results: </bold>It was shown that (i) RAGE expression gradually increased in normal endometrium, well-differentiated endometrial cancer, and poorly-differentiated endometrial cancer, respectively; (ii) a positive correlation existed between RAGE and microvessel density in human endometrial cancer samples; (iii) RAGE knockdown was effective in decreasing microvessel formation in xenografted tumour models; and (iv) RAGE knockdown can significantly inhibit the proliferation of endometrial cancer cells in vivo.<bold>Conclusions: </bold>These results indicate that RAGE may be a potential trigger in microvascular formation and proliferation in the development of endometrial cancer.
- Subjects
ADVANCED glycation end-products; ENDOMETRIAL cancer; CANCER invasiveness; GENE expression; SMALL interfering RNA; XENOGRAFTS; ANIMAL experimentation; BLOOD vessels; CELL lines; CELL physiology; GENES; GENETIC techniques; MICE; TRANSFERASES; TUMOR antigens; ENDOMETRIAL tumors
- Publication
BMC Cancer, 2016, Vol 16, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-016-2126-3