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- Title
Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway
- Authors
Bianco, Caterina; Mysliwiec, Margaret; Watanabe, Kazuhide; Mancino, Mario; Nagaoka, Tadahiro; Gonzales, Monica; Salomon, David S.
- Abstract
Abstract: Cripto-1, a co-receptor for Nodal, can activate Nodal-dependent and Nodal-independent signaling pathways. In this study we have investigated whether Cripto-1 mutants, that fail to activate a Nodal-dependent signaling pathway, are capable to activate a Nodal-independent signaling pathway in mammary epithelial cells. Cripto-1 mutants expressed in EpH4 mouse mammary epithelial cells are fully functional in regard to activation of a Nodal-independent signaling pathway, leading to phosphorylation of mitogen-activated protein kinase (MAPK) and Akt and to enhanced proliferation and motility of these cells, suggesting that Cripto-1 mutants with impaired Nodal signaling are still active in a Nodal-independent signaling pathway. Structured summary: MINT-6797299: Glypican 1 (uniprotkb:P35052) physically interacts (MI:0218) with Cr 1 (uniprotkb:P13385) by anti bait coimmunoprecipitation (MI:0006)
- Subjects
CELLULAR signal transduction; GENETIC regulation; GENETIC repressors; EPITHELIAL cells; PROTEOGLYCANS; GENETIC mutation; MITOGEN-activated protein kinases
- Publication
FEBS Letters, 2008, Vol 582, Issue 29, p3997
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.10.052