We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development.
- Authors
Nelson, Daryl O.; Jin, Dexter X.; Downs, Karen M.; Kamp, Timothy J.; Lyons, Gary E.
- Abstract
COVER PHOTOGRAPH: A merged confocal image of a primary cardiomyocyte culture, derived from the ventricles of a postnatal day-3 mouse heart. Cardiomyocytes were co-stained with primary antibodies to IRX4, a ventricle-specific transcription factor, and the cardiomyocyte-specific marker, cardiac troponin T. A goat anti-mouse IgM Alexa 568 secondary (red) was used to detect IRX4 primary antibody, and goat anti-mouse IgG Alexa 488 secondary (green) was used to report localization of the cardiac troponin T primary antibody. Nuclei were labeled with Hoechst dye. This result shows that IRX4 is restricted to the cytoplasm of postnatal day 3 ventricular myocytes. At postnatal day 5, IRX4 is localized to the nuclei of cardiomyocytes. From Nelson et al., Developmental Dynamics 243:381-392.
- Publication
Developmental Dynamics, 2014, Vol 243, Issue 3, pC1
- ISSN
1058-8388
- Publication type
Other
- DOI
10.1002/dvdy.24045