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- Title
Duration of intrapartum antibiotics for group B streptococcus on the diagnosis of clinical neonatal sepsis.
- Authors
Turrentine, Mark A.; Greisinger, Anthony J.; Brown, Kimberly S.; Wehmanen, Oscar A.; Mouzoon, Melanie E.
- Abstract
<bold>Background: </bold>Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis.<bold>Materials and Methods: </bold>A retrospective cohort study of women-infant dyads undergoing IAP for GBS at ≥37-week gestation who presented in labor from January 1, 2003 through December 31, 2007 was performed. Infants diagnosed with clinical sepsis by the duration of maternal IAP received (< or ≥4-hours duration) were determined.<bold>Results: </bold>More infants whose mothers received <4 hours of IAP were diagnosed with clinical sepsis, 13 of 1,149 (1.1%) versus 15 of 3,633 (0.4%), P = .03. Multivariate logistic regression analysis showed that treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16-0.79, and P = .01.<bold>Conclusion: </bold>The rate of neonatal clinical sepsis is increased in newborns of GBS colonized mothers who receive <4 hours compared to ≥4 hours of IAP.
- Subjects
SEPSIS; STREPTOCOCCUS agalactiae; ANTIBIOTICS; INFANT diseases; MULTIVARIATE analysis
- Publication
Infectious Diseases in Obstetrics & Gynecology, 2013, p1
- ISSN
1064-7449
- Publication type
journal article
- DOI
10.1155/2013/525878