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- Title
A retrospective analysis of the prevalence and clinical outcomes of vitamin D deficiency in myeloma patients in tropical Australia.
- Authors
Nath, Karthik; Ganeshalingam, Vibooshini; Ewart, Barbara; Heyer, Elizabeth; Watt, Kerrianne; Birchley, Andrew; Casey, John; Lai, Hock Choong; Morris, Edward; Hodges, Georgina
- Abstract
<bold>Purpose: </bold>The aim of this descriptive study was to assess the prevalence of vitamin D deficiency in patients on active therapy for multiple myeloma in a tropical climate. We also tested for the association of vitamin D status on clinical outcomes.<bold>Methods: </bold>This was a single centre, observational study performed in Townsville, Australia, which has a sunlight heavy, tropical climate. Patients on active therapy for multiple myeloma underwent testing of serum 25-hydroxyvitamin D (25(OH)D). Information on disease stage, skeletal morbidity and symptoms of peripheral neuropathy were collected from medical records and self-reported patient questionnaires.<bold>Results: </bold>A total of 41 patients were included. With a median disease duration of 38 months, 27% were found to be vitamin D deficient. Patients with vitamin D deficiency had a higher likelihood of peripheral neuropathy compared with their non-vitamin D counterparts (73% vs. 33%, P = 0.03). Although those with vitamin D deficiency had more skeletal morbidity, this was not statistically significant (73% vs 50%, P = 0.19). Reduced 25(OH) D was associated with a poor performance status (P = 0.003). There was no association between vitamin D status and stage of myeloma.<bold>Conclusion: </bold>There is a relatively high prevalence of vitamin D deficiency in patients with myeloma in our study. This is despite a sunlight heavy, tropical climate. We report an association between vitamin D deficiency and peripheral neuropathy. Prospective interventional trials are required to further assess this.
- Subjects
TOWNSVILLE (Qld.); AUSTRALIA; VITAMIN D deficiency; MONOCLONAL gammopathies; TROPICAL climate; VITAMIN D; RETROSPECTIVE studies; PERIPHERAL neuropathy; DISEASE prevalence; MULTIPLE myeloma; DISEASE complications
- Publication
Supportive Care in Cancer, 2020, Vol 28, Issue 3, p1249
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-019-04942-7