We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
c-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments.
- Authors
Busquets, Oriol; Ettcheto, Miren; Eritja, Àuria; Espinosa-Jiménez, Triana; Verdaguer, Ester; Olloquequi, Jordi; Beas-Zarate, Carlos; Castro-Torres, Ruben Dario; Casadesús, Gemma; Auladell, Carme; Bulló, Mònica; Folch, Jaume; Camins, Antoni
- Abstract
The development of metabolic alterations like insulin resistance has been associated with dysfunctions in mitochondrial oxidative capacity, induction of neuroinflammatory responses, and the appearance of cognitive impairments in the brain. The c-Jun N-terminal Kinase 1 (JNK1) is a potential key modulator of these mechanisms. The current study identifies a protective effect of whole-body JNK1 knockout in the presence of a high-fat diet (HFD). Specifically, the data suggest that mice missing JNK1 show increased insulin sensitivity and mitochondrial activity, as well as reduced body weight, and astrocyte and microglial reactivity. Finally, these animals are also protected against HFD-induced cognitive impairments as assessed through novel object recognition test, the observation of dendritic spines, and the levels of BDNF or other proteins like spinophilin and ARC. Thus, modulation of JNK1 activity seems like a promising approach for the design of therapies aimed at treating metabolic-induced cognitive impairments. Key messages: JNK1 is a link between obesity/type 2 diabetes and cognitive loss Inhibition of JNK1 is neuroprotective JNK1 constitutes a therapeutic strategy for cognitive loss.
- Subjects
DENDRITIC spines; COGNITION disorders; TYPE 2 diabetes; HIGH-fat diet; INSULIN resistance; BODY weight
- Publication
Journal of Molecular Medicine, 2019, Vol 97, Issue 12, p1723
- ISSN
0946-2716
- Publication type
Article
- DOI
10.1007/s00109-019-01856-z