We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database.
- Authors
Shi, Lucy L.; McMullen, Caitlin; Vorwald, Kathryn; Nichols, Anthony C.; MacNeil, S. Danielle; Wadsworth, J. Trad; Chung, Christine H.; Wang, Xuefeng; Patel, Krupal B.
- Abstract
Background: Subglottic squamous cell carcinoma (SCC) represents less than 5% of all laryngeal cancers. Our objective was to better characterize survival using the National Cancer Database (NCDB) registry from 2004 to 2015. Results: 403 patients met inclusion criteria. 63.8% presented with advanced-stage disease. Treatment regimens were as follows: 15.9% underwent surgery alone, 16.9% underwent surgery followed by adjuvant therapy, and 67.2% underwent primary chemo/radiation (C/RT). Five-year overall survival (OS) was 58.6% for Stage I and II patients, 49.1% for Stage III, and 36.3% for stage IV. Adjusted OS for all-stage patients was worse with C/RT compared to upfront surgery (40.6% vs. 58.4%; HR 1.83 [95%CI 1.29–2.61] p < 0.001) and adjusted OS for stage 4 disease was significantly worse with C/RT compared to surgery (26.0% vs. 45.2%, HR 1.79 [95%CI 1.17–2.73] p = 0.007). Conclusion: Majority of patients were treated with primary C/RT. Adjusted survival favors upfront surgery versus C/RT, especially in patients with Stage IV disease.
- Subjects
SURVIVAL rate; OVERALL survival; SQUAMOUS cell carcinoma; TREATMENT effectiveness; LARYNGEAL cancer
- Publication
European Archives of Oto-Rhino-Laryngology, 2021, Vol 278, Issue 12, p4923
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-021-06712-w