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- Title
The Clinical Impact of the Pretreatment Platelet-to-Lymphocyte Ratio in Gastric Cancer Patients Who Receive Curative Treatment.
- Authors
TORU AOYAMA; ITARU HASHIMOTO; YUKIO MAEZAWA; KENTARO HARA; KEISUKE KAZAMA; MASAKATSU NUMATA; NATSUMI KAMIYA; HIROSHI TAMAGAWA; SHO SAWAZAKI; SHINNOSUKE KAWAHARA; KEISUKE KOMORI; AYAKO TAMAGAWA; HARUHIKO CHO; JUNYA MORITA; KAZUKI OTANI; AYA KATO; MIE TANABE; TAKASHI OSHIMA; NORIO YUKAWA; AYA SAITO
- Abstract
Background/Aim: The platelet-to-lymphocyte ratio (PLR) is a promising prognostic marker in some malignancies. The present study evaluated the clinical impact of the PLR in patients with gastric cancer who underwent curative resection. Patients and Methods: This study included 258 patients who underwent curative treatment for gastric cancer between 2005 and 2020. The prognosis and clinicopathological parameters between the high- and low- PLR statuses were analyzed. Results: The overall survival (OS) stratified by each clinical factor was compared using the log-rank test, and a significant difference was observed using a pretreatment PLR of 150. When comparing the patient backgrounds between the high-PLR (PLR≥150) and low-PLR (PLR<150) groups, there were no significant differences between the two groups. The OS rates at 3 and 5 years after surgery were significantly higher at 70.8% and 60.4%, respectively, for the high-PLR group than at 83.6% and 79.7%, respectively, for the low-PLR group. Univariate and multivariate analyses of the OS showed that the PLR was a significant prognostic factor. In addition, when comparing the first recurrence sites, there were significant differences in peritoneal recurrence. Conclusion: The PLR is a significant risk factor for gastric cancer, making it a promising prognostic factor for patients with gastric cancer.
- Subjects
STOMACH cancer treatment; BLOOD platelets; LYMPHOCYTES; CLINICAL trials; MULTIVARIATE analysis
- Publication
In Vivo, 2023, Vol 37, Issue 6, p2696
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13379