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- Title
THE miR-196a2T/C VARIANT AS A POSSIBLE PREDISPOSING FACTOR FOR ANKYLOSING SPONDYLITIS IN A TURKISH POPULATION.
- Authors
PEHLİVAN, Sacide; GURSOY, Savaş; NURSAL, Ayşe Feyda; KALTUN, Mazlum Serdar; OZDİLLİ, Kurşat; PEHLİVAN, Mustafa
- Abstract
Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of several diseases. Therefore, we aimed to explore the effects of miR-196a2T/C (rs11614913) variant profile on susceptibility to AS in a Turkish population. Materials and Methods: Blood samples were collected from 78 AS patients and 79 healthy controls. miR-196a2T/C variant was genotyped by PCR-RFLP. Odds ratio (OR) with 95% confidence interval (95%CI) were calculated using the ?2 test. Results: The frequency of T/C and T/T genotypes of the miR- 196a2T/C were higher in AS patients compared to healthy controls (p=0.034 and p=0.028, respectively). The subjects carrying the miR-196a2T/C variant T/T genotype showed a 2.542-fold increased AS risk than the control group. However, no difference was observed in the allele frequencies of miR-196a2T/C between AS patients and the controls. It was found that C/C genotype of miR-196a2T/C variant was more frequent in AS patients with enthesitis than AS patients without enthesitis (p=0.042). Conclusion: The miR-196a2T/C variant represents a genetic risk factor for increased susceptibility to AS and is associated with enthesitis in the Turkish population.
- Subjects
ANKYLOSING spondylitis; TUMOR suppressor genes; PATHOLOGY; LOSS control; GENE frequency; ODDS ratio
- Publication
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi, 2020, Vol 83, Issue 2, p81
- ISSN
1305-6441
- Publication type
Article
- DOI
10.26650/IUITFD.2019.0023