We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An association of periostin levels with the severity and chronicity of atopic dermatitis in children.
- Authors
Sung, Myongsoon; Lee, Kyung Suk; Ha, Eun Gyo; Lee, Seung Jin; Kim, Mi Ae; Lee, Seung Won; Jee, Hye Mi; Sheen, Youn Ho; Jung, Young Ho; Han, Man Yong
- Abstract
Background Serum periostin might be a biomarker in the pathogenesis of T helper 2-type allergic diseases. The aim of this study was to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis ( AD) in children. Methods This population-based study examined 4076 children aged 4 to 13 years between June 2015 and July 2015. Of the 4076 children, 196-137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control ( HC) group-were included for the final analysis. Results Serum periostin levels were higher in the AD group than in the HC group ( P<.001) and were found to be positively associated with SCORAD score (Spearman's rho [ r]=.24, P=.001). Children with AD-onset time <2 years had significantly higher periostin levels ( P=.030) compared to those with AD-onset time ≥2 years. The total eosinophil ( P=.189) and IgE levels ( P=.140) were comparable between children with AD-onset time <2 years and those with AD-onset time ≥2 years. After adjustment for age, gender, and parental allergic history, serum periostin level ( OR: 1.03, 95% CI: 1.00-1.06, P=.046) contributed to the development of AD in children with AD-onset time <2 years. Conclusion Serum periostin level may play a role in the severity and chronicity of AD in children.
- Subjects
ATOPIC dermatitis; PERIOSTIN; BIOMARKERS; ALLERGY in children; BLOOD serum analysis; CHILDREN'S health; PROGNOSIS
- Publication
Pediatric Allergy & Immunology, 2017, Vol 28, Issue 6, p543
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12744