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- Title
Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.
- Authors
Hirakawa, Hitoshi; Ikegami, Taro; Kise, Norimoto; Kinjyo, Hidetoshi; Kondo, Shunsuke; Agena, Shinya; Hasegawa, Narumi; Kawakami, Junko; Maeda, Hiroyuki; Suzuki, Mikio
- Abstract
This study aimed to clarify the roles of high-risk human papillomavirus (HR-HPV) infection and epidermal growth factor receptor (EGFR) exon 20 mutations in sinonasal inverted papilloma (IP) and sinonasal squamous cell carcinoma (SNSCC). Samples were collected from 20 cases with IP, 7 with IP and squamous cell carcinoma (IP-SCC), and 20 with SNSCC and examined for HPV infection and EGFR exon 20 mutations. Low- or high-risk HPV DNA was observed in 25% of IP, 57.1% of IP-SCC, and 35% of SNSCC cases. Transcriptionally active HR-HPV infections in IP-SCC and SNSCC, accompanied by p16 overexpression, were observed in 28.5% and 25% of cases, respectively. Heterozygous EGFR exon 20 amino acid insertions (ex20ins), located between amino acids 768–774, were observed in 45% of IP, 28.5% of IP-SCC, and 0% of SNSCC and chronic sinusitis cases. EGFR phosphorylation sites were located at tyrosine (Y) 845, Y1068, Y1086, and Y1197 and induced PI3K/AKT/mTOR activation. The phosphorylation pattern of EGFR with ex20ins resembled that of HPV-related SNSCC and oropharyngeal cancer. The transcriptionally active HR-HPV infection and ex20ins might be responsible for the pathogenesis of IP-SCC cases with different fashions. Since IP-SCC might be a multifactorial disease, further investigation is needed to understand IP-SCC etiology.
- Subjects
HUMAN papillomavirus; SQUAMOUS cell carcinoma; PAPILLOMAVIRUS diseases; EPIDERMAL growth factor receptors; PARANASAL sinuses
- Publication
Journal of Personalized Medicine, 2023, Vol 13, Issue 4, p657
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm13040657