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- Title
Stress-induced priming of glutamate synapses unmasks associative short-term plasticity.
- Authors
Kuzmiski, J. Brent; Marty, Vincent; Baimoukhametova, Dinara V.; Bains, Jaideep S.
- Abstract
Exposure to a stressor sensitizes or 'primes' the hypothalamic-pituitary-adrenal axis to a subsequent novel stressor. The synaptic mechanisms underlying this priming, however, are not known. We found that exposing a rat to a single stressor primed glutamate synapses in the paraventricular nucleus of the hypothalamus and allowed them to undergo a short-term potentiation (STP) following a burst of high-frequency afferent activity. This transient potentiation requires a corticotrophin-releasing hormone-dependent depression of postsynaptic NMDA receptors (NMDARs). The long-term depression of NMDAR function after stress prevented the vesicular release of an inhibitory retrograde messenger that, in control conditions, arrests STP. Following stress, STP manifested as an increase in the release probability of glutamate that was sufficient to induce multivesicular release. Our findings indicate that the priming of synapses to express STP is a synaptic correlate to stress-induced behavioral and neuroendocrine sensitization.
- Subjects
PSYCHOLOGICAL stress; SYNAPSES; PHYSIOLOGICAL adaptation; LABORATORY rats; HYPOTHALAMUS; GLUTAMIC acid
- Publication
Nature Neuroscience, 2010, Vol 13, Issue 10, p1257
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2629