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- Title
Agnoprotein and its coding sequences play regulatory roles in JC virus gene transcription and replication in glial cells.
- Authors
Safak, M.; Biffi, R.; Radhakrishnan, S.; Wooliridge, S.; Sairiyeir, I. K.; Akan, I.; Gordon, J.; Amini, S.; Ferrante, P.; Khalili, K.
- Abstract
It has been suspected that human neurotropic virus, JC virus, late agnoprotein may play regulatory roles in JCV gene transcription and replication. Here, we investigated the importance of this protein and its coding sequences in such processes by using point (Pt) and deletion mutants of the virus. Results from transcription studies showed that expression of viral early and late genes was substantially decreased in cells transfected with agnoprotein Pt mutant and completely abolished in cells transfected with agnoprotein deletion mutant compared to wild type.
- Subjects
NEUROPHARMACOLOGY; GENETIC transformation; PROTEINS; GENES; CELLS; VIRUS diseases
- Publication
Journal of NeuroVirology, 2004, Vol 10, p43
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1080/13550280490469833