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- Title
Chemotherapy with rituximab followed by high‐dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma.
- Authors
Catherine Thieblemont; Daciana Antal; Laurence Lacotte‐Thierry; Vincent Delwail; Daniel Espinouse; Anne‐Sophie Michallet; Catherine Traulle; Fadhela Bouafia‐Sauvy; Christine Giraud; Gilles Salles; François Guilhot; Bertrand Coiffier
- Abstract
The authors evaluated the efficacy of chemotherapy combined with rituximab followed by high‐dose therapy (HDT) plus autologous stem cell transplantation in patients with mantle cell lymphoma (MCL).This was a retrospective analysis of 34 patients who were treated in 2 departments of hematology, including 29 patients (85%) who received first‐line treatment. Rituximab was administered as 4 injections just before harvest in 25 patients (73%) or simultaneously with chemotherapy in 9 patients (27%). HDT included total body irradiation in 26 patients (77%).After induction therapy, all patients except one reached a response: There were 14 (41%) complete responses (CR) and 19 (56%) partial responses (PR). Stem cell harvest was successful in all patients but 2, with a median number of 5.9 CD34‐positive cells per 106/kg. Three months after transplantation, 24 patients (71%) were in CR, and 7 patients (21%) were in PR. At 3 years from the day of transplantation, the estimated overall survival was 87%. With a median follow‐up at 2.6 years, the estimated median time to disease progression was 3.4 years. Rituximab treatment before harvest did not delay hematopoietic reconstitution: The median time it took patients to recover absolute neutrophil count to > 0.5 G/L was 10 days.Chemotherapy combined with rituximab followed by HDT improved the overall survival and progression‐free survival in patients MCL without adding toxicities. Cancer 2005. © 2005 American Cancer Society.
- Publication
Cancer (0008543X), 2005, Vol 104, Issue 7, p1434
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.21313