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- Title
Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran.
- Authors
Mohaddes Ardebili, Seijed Mojtaba; Yeghaneh, Tarlan; Gharesouran, Jalal; Rezazadeh, Maryam; Farhoudi, Mehdi; Ayromlou, Hormoz; Talebi, Mahnaz; Ghojazadeh, Morteza
- Abstract
BACKGROUND: Recent findings suggest that production of pro-inflammatory cytokines, such as Tumour Necrosis Factor-alpha (TNF- α), is increased in the brain tissue of patients suffering late-onset Alzheimer's disease (LOAD) and play an important role in the pathogenesis of this disease. Several epidemiological studies also suggest that patients taking anti-inflammatory drugs have a decreased risk of developing AD. TNF- α is an important pro inflammatory cytokine that is unregulated in Alzheimer's patients. Functional polymorphisms in tumor necrosis factor alpha (TNF-α) can affect immune response, inflammation, tissue injury and possibly the susceptibility to Alzheimer disease (AD). METHODS: We used the polymorphic DNA markers (-308G/A) and (-863C/A) to study the association of TNF-α gene mutations with Late-onset Alzheimer's disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. RESULTS: Our data showed significant difference in TNF-α-308 G/A genotype and pro inflammatory cytokine allele frequencies between the Alzheimer disease patients and healthy subjects. Contrary to that, no significant difference was observed in TNF-α-863 C/A genotype and allele frequencies between these two groups. CONCLUSIONS: TNF-α-308 G/A gene polymorphism could affect cerebral inflammatory response and the risk of late onset Alzheimer disease but -863C/A polymorphism does not influence the risk of this disease and this possible association between TNF-α -308G/A and -863C/A gene polymorphisms have to be further elucidated in larger case control studies.
- Subjects
IRAN; GENETICS of Alzheimer's disease; TUMOR necrosis factors; GENETIC polymorphisms; AZERBAIJANIS
- Publication
Journal of Research in Medical Sciences, 2011, Vol 16, Issue 8, p1006
- ISSN
1735-1995
- Publication type
Article