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- Title
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
- Authors
Babińska, Anna; Pęksa, Rafał; Wiśniewski, Piotr; Sworczak, Krzysztof
- Abstract
<bold>Introduction: </bold>The role of adipokines in neoplasms not related to obesity is unclear. The presence of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) as well as the leptin receptor (Ob-R) has been recognized in human adrenal tumors. The authors of the present study were the first to compare the expression of these receptors in histopathologically distinct adrenal tumors.<bold>Material and Methods: </bold>The study encompassed tissue specimens of 128 patients with adrenal tumors (28 adrenal cortical adenomas (CA), 35 cortical nodular hyperplasia tumors (CNH), 20 cortical carcinomas (CC), 40 pheochromocytomas (PHEO), 5 malignant pheochromocytomas (PHEOM)) operated on at a single clinical center. The expression of the adiponectin receptors AdipoR1 and AdipoR2 as well as the leptin receptor Ob-R was assessed by immunohistochemistry. The results were correlated with body mass index (BMI) and gender of the patients.<bold>Results: </bold>AdipoR1 expression was significantly higher in cortical cancers (p < 0.001) and pheochromocytomas (p < 0.001) as compared to benign cortical tumors. AdipoR2 expression was significantly higher in cortical carcinomas as compared to cortical adenomas and hyperplasia tumors (p = 0.01), and also significantly higher in pheochromocytomas in comparison to adrenocortical cancers (p = 0.004). Leptin receptor expression was absent or minimal in half of nodular hyperplasia tumors and adrenal cortex adenomas. This receptor's expression was significantly higher in adrenocortical cancers (p = 0.038). In pheochromocytomas this receptor was expressed more abundantly than in adrenocortical cancers (p = 0.004).<bold>Conclusions: </bold>These novel findings suggest that adiponectin and leptin receptors could play a regulatory role in human adrenal neoplasms.
- Subjects
LEPTIN receptors; ADRENAL tumors; BENIGN tumors; ADRENAL cortex; BODY mass index; ADENOMATOUS polyps
- Publication
Archives of Medical Science, 2019, Vol 15, Issue 5, p1254
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms.2018.76142