We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Relative Effectiveness of Cell-Cultured and Egg-Based Influenza Vaccines Among Elderly Persons in the United States, 2017-2018.
- Authors
Izurieta, Hector S; Chillarige, Yoganand; Kelman, Jeffrey; Wei, Yuqin; Lu, Yun; Xu, Wenjie; Lu, Michael; Pratt, Douglas; Chu, Steve; Wernecke, Michael; MaCurdy, Thomas; Forshee, Richard
- Abstract
<bold>Background: </bold>The low influenza vaccine effectiveness (VE) observed during the A(H3N2)-dominated 2017-2018 season may be due to vaccine virus adaptation to growth in eggs. We compared the effectiveness of cell-cultured and egg-based vaccines among Medicare beneficiaries.<bold>Methods: </bold>Retrospective cohort study on Medicare beneficiaries aged ≥65 years who received an influenza vaccine (cell-cultured, egg-based quadrivalent; egg-based high-dose, adjuvanted, or standard-dose trivalent) during the 2017-2018 season. We used Poisson regression to evaluate relative VE (RVE) in preventing influenza-related hospital encounters.<bold>Results: </bold>Of >13 million beneficiaries, RVE for cell-cultured vaccines relative to egg-based quadrivalent vaccines was 10% (95% confidence interval [CI], 7%-13%). In a midseason interim analysis, this estimate was 16.5% (95% CI, 10.3%-22.2%). In a 5-way comparison, cell-cultured (RVE, 11%; 95% CI, 8%-14%) and egg-based high-dose (RVE, 9%; 95% CI, 7%-11%) vaccines were more effective than egg-based quadrivalent vaccines.<bold>Conclusions: </bold>The modest VE difference between cell-cultured and egg-based vaccines only partially explains the low overall VE reported by the Centers for Disease Control and Prevention, suggesting that egg adaptation was not the main contributor to the low VE found among individuals aged ≥65 years. The midseason interim analysis we performed demonstrates that our methods can be used to evaluate VE actively during the influenza season.
- Subjects
INFLUENZA vaccines; OLDER people; CENTERS for Disease Control &; Prevention (U.S.); VIRAL vaccines; VACCINE effectiveness; POISSON regression
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 8, p1255
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy716