We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association Analysis Suggests SOD2 as a Newly Identified Candidate Gene Associated With Leprosy Susceptibility.
- Authors
Brotto Ramos, Geovana; Salomão, Heloisa; Schneider Francio, Angela; Medeiros Fava, Vinícius; Werneck, Renata Iani; Távora Mira, Marcelo; Ramos, Geovana Brotto; Francio, Angela Schneider; Fava, Vinícius Medeiros; Mira, Marcelo Távora
- Abstract
Genetic studies have identified several genes and genomic regions contributing to the control of host susceptibility to leprosy. Here, we test variants of the positional and functional candidate gene SOD2 for association with leprosy in 2 independent population samples. Family-based analysis revealed an association between leprosy and allele G of marker rs295340 (P = .042) and borderline evidence of an association between leprosy and alleles C and A of markers rs4880 (P = .077) and rs5746136 (P = .071), respectively. Findings were validated in an independent case-control sample for markers rs295340 (P = .049) and rs4880 (P = .038). These results suggest SOD2 as a newly identified gene conferring susceptibility to leprosy.
- Subjects
HANSEN'S disease; HANSEN'S disease patients; DISEASE susceptibility; ALLELES; GENETIC carriers; GENETICS
- Publication
Journal of Infectious Diseases, 2016, Vol 214, Issue 3, p475
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw170