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- Title
Quantitative Assessment of the Subepithelial Collagen Band Does Not Increase the Accuracy of Diagnosis of Collagenous Colitis.
- Authors
Carlos Rubio; Abiel Orrego; Anders Höög; Anja Porwitz; Fredrik Petersson; Göran Elmberger; Axel Glaessgen; Elina Eriksson; Lena Kanter; Georg Jaremko; Lars Egevad; M. Liljefors; Britta Löfdahl; Peter Norman; Olle Larsson; Johan Wejde; Peter Zickert; Jan Björk
- Abstract
The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results failed to diagnose CC; by calibrated micrometry, the failure was 6% and by semiautomatic micrometry, 6%. The main difficulty in measuring the thickness of the CC band is that the deeper border of the band appears fuzzy and hairy-irregular. CC should be defined not exclusively on the basis of the thickness of the collagen table, but as a microscopic constellation characterized by a distorted superficial cell arrangement, with areas of epithelial denudation and inflammatory cells in the superficial epithelium and the lamina propria. In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"
- Subjects
COLITIS diagnosis; COLLAGEN diseases; MEDICAL technology; EOSINOPHILIA; EPITHELIAL cells; CLINICAL pathology; MICROMETERS; DIAGNOSIS
- Publication
American Journal of Clinical Pathology, 2008, Vol 130, Issue 3, p375
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/K7MH8UCK3MR7Q77L