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- Title
African Mitochondrial DNA Subhaplogroups and Peripheral Neuropathy during Antiretroviral Therapy.
- Authors
Canter, Jeffrey A.; Robbins, Gregory K.; Selph, Doug; Clifford, David B.; Kallianpur, Asha R.; Shafer, Robert; Levy, Shawn; Murdock, Deborah G.; Ritchie, Marylyn D.; Haas, David W.; Hulgan, Todd
- Abstract
Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.
- Subjects
HIV; AIDS; MITOCHONDRIAL DNA; HIGHLY active antiretroviral therapy; ANTIVIRAL nucleosides; REVERSE transcriptase; ANTIVIRAL agents; MITOCHONDRIAL pathology; AFRICANS
- Publication
Journal of Infectious Diseases, 2010, Vol 201, Issue 11, p1703
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/652419