We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antibody Maturation and Viremia after Primary Cytomegalovirus Infection, in Immunocompetent Patients and Kidney-Transplant Patients.
- Authors
Steininger, Christoph; Kundi, Michael; Kletzmayr, Josef; Aberle, Stephan W.; Popow-Kraupp, Theresia
- Abstract
To investigate antibody maturation and serum levels of cytomegalovirus (CMV) DNA after primary CMV infection, we studied 51 immunocompetent and 27 kidney-transplant patients. Compared with the immunocompetent patients, the transplant patients had significantly more-prolonged and -variable antibody maturation, clearly longer durations of viremia, and higher levels of CMV DNA; however, antibody maturation continued for >1 year even in immunocompetent patients. Long-term ganciclovir prophylaxis in the transplant patients was associated with either delayed immunoglobulin- G seroconversion, inhibition of antibody maturation (n = 2), or immunoglobulin-class switching (n = 1). In conclusion, antibody maturation continues in immunocompetent patients for a period longer than previously had been thought and is significantly delayed or even inhibited in kidney-transplant patients.
- Subjects
CYTOMEGALOVIRUS diseases; CYTOMEGALOVIRUSES; IMMUNOLOGIC diseases; KIDNEY transplantation; IMMUNOGLOBULINS; GANCICLOVIR
- Publication
Journal of Infectious Diseases, 2004, Vol 190, Issue 11, p1908
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/424677