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Preclinical target validation using patient-derived cells.
- Published in:
- Nature Reviews Drug Discovery, 2015, v. 14, n. 3, p. 149, doi. 10.1038/nrd4565
- By:
- Publication type:
- Article
A generalizable pre-clinical research approach for orphan disease therapy.
- Published in:
- 2012
- By:
- Publication type:
- journal article
A generalizable pre-clinical research approach for orphan disease therapy.
- Published in:
- Orphanet Journal of Rare Diseases, 2012, v. 7, n. 1, p. 39, doi. 10.1186/1750-1172-7-39
- By:
- Publication type:
- Article
The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding.
- Published in:
- EMBO Journal, 1999, v. 18, n. 16, p. 4498, doi. 10.1093/emboj/18.16.4498
- By:
- Publication type:
- Article
The Emory‐Sage‐SGC TREAT‐AD Center: Tool development for novel targets in Alzheimer's Disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.076912
- By:
- Publication type:
- Article
The Emory‐Sage‐SGC TREAT‐AD Center: Tool and probe development for emerging targets in Alzheimer's Disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.064748
- By:
- Publication type:
- Article
Tool and chemical probe development for emerging targets in Alzheimer's disease: The Emory‐Sage‐SGC TREAT‐AD Center.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051447
- By:
- Publication type:
- Article
2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Has Characteristics of Cytoskeletal Proteins A Hypothesis for Its Function<sup>a</sup>.
- Published in:
- Annals of the New York Academy of Sciences, 1990, v. 605, n. 1, p. 55, doi. 10.1111/j.1749-6632.1990.tb42380.x
- By:
- Publication type:
- Article
Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid.
- Published in:
- Liver International, 2008, v. 28, n. 7, p. 997, doi. 10.1111/j.1478-3231.2008.01744.x
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- Publication type:
- Article
Donated chemical probes for open science.
- Published in:
- eLife, 2018, p. 1, doi. 10.7554/eLife.34311
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- Publication type:
- Article
In situ proteolysis for protein crystallization and structure determination.
- Published in:
- Nature Methods, 2007, v. 4, n. 12, p. 1019, doi. 10.1038/nmeth1118
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- Publication type:
- Article
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair.
- Published in:
- Molecular Microbiology, 2011, v. 79, n. 2, p. 484, doi. 10.1111/j.1365-2958.2010.07465.x
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- Publication type:
- Article
RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability.
- Published in:
- Yeast, 1993, v. 9, n. 3, p. 295, doi. 10.1002/yea.320090309
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- Publication type:
- Article
Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.
- Published in:
- Proteins, 2004, v. 54, n. 3, p. 455, doi. 10.1002/prot.10620
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- Publication type:
- Article
X-ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution (The submitted manuscript has been created by the University of Chicago as Operator of Argonne National Laboratory (Argonne) under Contract No. W-31-109-ENG-38 with the U.S. Department of Energy. The U.S. Government retains for itself, and others acting on its behalf, a paid-up, nonexclusive, irrevocable worldwide license in said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government.)
- Published in:
- Proteins, 2004, v. 54, n. 1, p. 162, doi. 10.1002/prot.10585
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- Publication type:
- Article
Strategies for structural proteomics of prokaryotes: Quantifying the advantages of studying orthologous proteins and of using both NMR and X-ray crystallography approaches.
- Published in:
- Proteins, 2003, v. 50, n. 3, p. 392, doi. 10.1002/prot.10282
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- Publication type:
- Article
Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.
- Published in:
- Proteins, 2003, v. 50, n. 2, p. 177, doi. 10.1002/prot.10311
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- Publication type:
- Article
NMR structure of the Escherichia coli protein YacG: A novel sequence motif in the zinc-finger family of proteins.
- Published in:
- Proteins, 2002, v. 49, n. 2, p. 289, doi. 10.1002/prot.10214
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- Publication type:
- Article
Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold.
- Published in:
- Proteins, 2002, v. 48, n. 1, p. 141, doi. 10.1002/prot.10147
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- Publication type:
- Article
NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli.
- Published in:
- Proteins, 2002, v. 47, n. 4, p. 572, doi. 10.1002/prot.10120
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- Publication type:
- Article
Highlights of B/D-HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics.
- Published in:
- 2014
- By:
- Publication type:
- Other
Could open science stimulate industry partnerships in chemical engineering university research?
- Published in:
- Canadian Journal of Chemical Engineering, 2021, v. 99, n. 10, p. 2186, doi. 10.1002/cjce.24077
- By:
- Publication type:
- Article
MAID : An effect size based model for microarray data integration across laboratories and platforms.
- Published in:
- BMC Bioinformatics, 2008, v. 9, p. 1, doi. 10.1186/1471-2105-9-305
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- Publication type:
- Article
Too many roads not taken.
- Published in:
- 2011
- By:
- Publication type:
- Opinion
Crystal structure of the CorA Mg<sup>2+</sup> transporter.
- Published in:
- 2006
- By:
- Publication type:
- Letter
SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics.
- Published in:
- Nucleic Acids Research, 2001, v. 29, n. 13, p. 2884, doi. 10.1093/nar/29.13.2884
- By:
- Publication type:
- Article
Ten Simple Rules for Cultivating Open Science and Collaborative R&D.
- Published in:
- 2013
- By:
- Publication type:
- Editorial
Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.91645
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- Publication type:
- Article
Leveraging Crowdsourcing to Facilitate the Discovery of New Medicines.
- Published in:
- Science Translational Medicine, 2011, v. 3, n. 88, p. 1, doi. 10.1126/scitranslmed.3002678
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- Publication type:
- Article
Corrigendum: The promise and peril of chemical probes.
- Published in:
- Nature Chemical Biology, 2015, v. 11, n. 11, p. 887, doi. 10.1038/nchembio1115-887c
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- Publication type:
- Article
The promise and peril of chemical probes.
- Published in:
- Nature Chemical Biology, 2015, v. 11, n. 8, p. 536, doi. 10.1038/nchembio.1867
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- Publication type:
- Article
Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases.
- Published in:
- PLoS Biology, 2007, v. 5, n. 5, p. e97, doi. 10.1371/journal.pbio.0050097
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- Publication type:
- Article
Letter to the Editor: NMR-based structure of the conserved protein MTH865 from the Archaeon Methanobacterium thermoautotrophicum.
- Published in:
- Journal of Biomolecular NMR, 2001, v. 21, n. 1, p. 63, doi. 10.1023/A:1011928105928
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- Publication type:
- Article
Letter to the Editor: 1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32 kDa subunit of human replication protein A.
- Published in:
- Journal of Biomolecular NMR, 2000, v. 17, n. 2, p. 179, doi. 10.1023/A:1008306832408
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- Publication type:
- Article
A practical and robust sequence search strategy for structural genomics target selection.
- Published in:
- Bioinformatics, 2004, v. 20, n. 14, p. 2288, doi. 10.1093/bioinformatics/bth240
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- Publication type:
- Article
Open drug discovery in Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2023, v. 9, n. 2, p. 1, doi. 10.1002/trc2.12394
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- Publication type:
- Article
Protein production: feeding the crystallographers and NMR spectroscopists.
- Published in:
- Nature Structural Biology, 2000, v. 7, p. 970, doi. 10.1038/80751
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- Publication type:
- Article
Phosphorylation of Myelin-Associated Glycoprotein In Vivo and In Vitro Occurs Only in the Cytoplasmic Domain of the Large Isoform.
- Published in:
- Journal of Neurochemistry, 1989, v. 52, n. 1, p. 317, doi. 10.1111/j.1471-4159.1989.tb10934.x
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- Publication type:
- Article
An open source plant kinase chemogenomics set.
- Published in:
- Plant Direct, 2022, v. 6, n. 11, p. 1, doi. 10.1002/pld3.460
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- Publication type:
- Article
A data science roadmap for open science organizations engaged in early-stage drug discovery.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49777-x
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- Publication type:
- Article
The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of α + β fold.
- Published in:
- Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 11, p. 2410, doi. 10.1002/pro.251
- By:
- Publication type:
- Article
The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii.
- Published in:
- Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 12, p. 3121, doi. 10.1110/ps.051821805
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- Publication type:
- Article
Protein folding: Defining a 'standard' set of experimental conditions and a preliminary kinetic data set of two-state proteins.
- Published in:
- Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 3, p. 602, doi. 10.1110/ps.041205405
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- Publication type:
- Article
Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins.
- Published in:
- Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 9, p. 2073, doi. 10.1110/ps.0393503
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- Publication type:
- Article
A novel member of the split βαβ fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae.
- Published in:
- Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 5, p. 1136, doi. 10.1110/ps.0240903
- By:
- Publication type:
- Article
Characterization of binding-induced changes in dynamics suggests a model for sequence-nonspecific binding of ssDNA by replication protein A.
- Published in:
- Protein Science: A Publication of the Protein Society, 2002, v. 11, n. 10, p. 2316, doi. 10.1110/ps.0209202
- By:
- Publication type:
- Article
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
- Published in:
- Protein Science: A Publication of the Protein Society, 2002, v. 11, n. 6, p. 1409, doi. 10.1110/ps.4720102
- By:
- Publication type:
- Article
Open access chemical and clinical probes to support drug discovery.
- Published in:
- Nature Chemical Biology, 2009, v. 5, n. 7, p. 436, doi. 10.1038/nchembio0709-436
- By:
- Publication type:
- Article
Gene Expression of the Central and Peripheral Nervous System Myelin Membrane 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase in Development.
- Published in:
- Developmental Neuroscience, 1988, v. 10, n. 2, p. 75, doi. 10.1159/000111958
- By:
- Publication type:
- Article
New approaches to rewarding pharmaceutical innovation.
- Published in:
- Canadian Medical Association Journal (CMAJ), 2011, v. 183, n. 6, p. 681, doi. 10.1503/cmaj.100375
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- Publication type:
- Article