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- Title
Potential Use of Vaccines in the Primary Prevention of Breast Cancer in High-Risk Patients.
- Authors
Lazzeroni, Matteo; Serrano, Davide
- Abstract
Cancer vaccines are an emerging therapeutic and prophylactic modality that may play a more important role in cancer prevention and treatment in the future. Therapeutic cancer vaccines are designed to generate a targeted, immune-mediated antitumor response. Successful prophylactic vaccines are those against oncogenic viral infections, such as the human papillomavirus and cervical cancer. However, a tough challenge for the majority of tumor vaccines is the self-nature of tumor antigens. Ongoing studies are investigating methods to enhance vaccine strategies including immune-modulating agents. The present review analyzes the potential use of vaccines in the primary prevention of breast cancer, focusing on the recent extension of vaccine target selection to self-proteins that are overexpressed during the early stages of tumor development but whose expression no longer occurs as we age, a feature that may avoid clinically significant autoimmune sequelae.
- Subjects
BREAST tumor prevention; BREAST tumors; VIRAL vaccines; WOMEN'S health
- Publication
Breast Care, 2012, Vol 7, Issue 4, p281
- ISSN
1661-3791
- Publication type
Journal Article
- DOI
10.1159/000342167