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- Title
Comparison of spontaneous brain activity in distinguishing parkinsonian variant of multiple system atrophy from Parkinson's disease at an early stage.
- Authors
Shichan Wang; Yi Xiao; Yanbing Hou; Chunyu Li; Lingyu Zhang; Ruwei Ou; Qianqian Wei; Junyu Lin; Tianmi Yang; Ningning Che; Qirui Jiang; Xiaoting Zheng; Jiyong Liu; Huifang Shang
- Abstract
Background: The overlapping clinical manifestations in parkinsonian variant of multiple system atrophy (MSA-P) and Parkinson's Disease (PD) can complicate clinical diagnostic accuracy, particularly in the early stage. The study aims to uncover the patterns of brain function in the initial phase of the two conditions. Methods: We recruited 24 MSA-P patients, 34 PD patients and 27 healthy controls (HC). Voxel-wise fractional amplitude of low-frequency fluctuation (fALFF) was compared to characterize regional brain function, followed by seedbased functional connectivity (FC) analysis. Receiver operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of fALFF. Results: Compared to HC, decreased fALFF was observed in the bilateral basal ganglia (BG) of MSA-P patients, while decreased fALFF was identified in the left BG of PD patients. Additionally, elevated fALFF was found in the superior cerebellum for MSA-P patients and the temporo-occipital cortex for PD patients. Furthermore, PD patients exhibited increased FC in the cortico-striatal loop compared to MSA-P patients. The fALFF of the left caudate distinguished MSA-P from HC with an area under the curve (AUC) of 0.838 (p < 0.001) and from PD with an AUC of 0.772 (p < 0.001). The fALFF of the left putamen distinguished PD from HC with an AUC of 0.736 (p = 0.002). Conclusion: Our findings indicated common and distinct abnormalities in spontaneous brain activity within BG, cerebellum, and cortices in early-stage MSA-P and PD patients. PD patients employed more compensatory mechanisms than MSA-P patients. Furthermore, fALFF may aid in early differentiation between MSA-P and PD.
- Subjects
BRAIN physiology; RESEARCH funding; RECEIVER operating characteristic curves; DATA analysis; T-test (Statistics); KRUSKAL-Wallis Test; SEX distribution; PARKINSON'S disease; MULTIPLE system atrophy; SYMPTOMS; MAGNETIC resonance imaging; CHI-squared test; MANN Whitney U Test; AGE distribution; DESCRIPTIVE statistics; PARKINSONIAN disorders; ONE-way analysis of variance; STATISTICS; EARLY diagnosis; COMPARATIVE studies; CEREBELLUM; DATA analysis software; EDUCATIONAL attainment
- Publication
Frontiers in Aging Neuroscience, 2024, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2024.1427991