We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses.
- Authors
Lam, Frederike; Leisegang, Matthias S.; Brandes, Ralf P.
- Abstract
The functional role of long noncoding RNAs in the endothelium is highly diverse. Among their many functions, regulation of transcription factor activity and abundance is one of the most relevant. This review summarizes the recent progress in the research on the lncRNA–transcription factor axes and their implications for the vascular endothelium under physiological and pathological conditions. The focus is on transcription factors critical for the endothelial response to external stressors, such as hypoxia, inflammation, and shear stress, and their lncRNA interactors. These regulatory interactions will be exemplified by a selected number of lncRNAs that have been identified in the endothelium under physiological and pathological conditions that are influencing the activity or protein stability of important transcription factors. Thus, lncRNAs can add a layer of cell type-specific function to transcription factors. Understanding the interaction of lncRNAs with transcription factors will contribute to elucidating cardiovascular disease pathologies and the development of novel therapeutic approaches.
- Subjects
TRANSCRIPTION factors; LINCRNA; VASCULAR endothelium; SHEARING force; GENETIC transcription regulation; PROTEIN stability
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 17, p9726
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25179726