We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cost-effectiveness of proton beam therapy vs. conventional radiotherapy for patients with brain tumors in Sweden: results from a non-randomized prospective multicenter study.
- Authors
Sampaio, Filipa; Langegård, Ulrica; de Alva, Patricio Martínez; Flores, Sergio; Nystrand, Camilla; Fransson, Per; Ohlsson-Nevo, Emma; Kristensen, Ingrid; Sjövall, Katarina; Feldman, Inna; Ahlberg, Karin
- Abstract
Background: This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden. Methods: Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demographic data were sourced from the longitudinal study and linked to Swedish national registers to get information on healthcare resource use. A cost-utility framework was used to evaluate the cost-effectiveness of PBT vs. CRT. Patients in PBT group (n = 310) were matched with patients in CRT group (n = 40) on relevant observables using propensity score matching with replacement. Costs were estimated from a healthcare perspective and included costs related to inpatient and specialized outpatient care, and prescribed medications. The health outcome was quality-adjusted life-years (QALYs), derived from the EORTC-QLQ-C30. Generalized linear models (GLM) and two-part models were used to estimate differences in costs and QALYs. Results: PBT yielded higher total costs, 14,639 US$, than CRT, 13,308 US$, with a difference of 1,372 US$ (95% CI, -4,914–7,659) over a 58 weeks' time horizon. Further, PBT resulted in non-significantly lower QALYs, 0.746 compared to CRT, 0.774, with a difference of -0.049 (95% CI, -0.195–0.097). The probability of PBT being cost-effective was < 30% at any willingness to pay. Conclusions: These results suggest that PBT cannot be considered a cost-effective treatment for brain tumours, compared to CRT. Trial registration: Not applicable. Novelty and Impact: This study informs on the cost-effectiveness of proton beam therapy (PBT) versus conventional radiotherapy (CRT) for patients with brain tumors in Sweden. Amidst global concerns regarding the cost-effectiveness of PBT, our investigation fills a notable gap by providing evidence from the Swedish healthcare landscape. Using real-world data, our study demonstrates the application of established health economic methodology to compare PBT and CRT for brain tumors, furthering research in this area.
- Subjects
SWEDEN; PROTON therapy; MEDICAL care use; QUALITY-adjusted life years; COST effectiveness; RADIOTHERAPY; RESEARCH funding; HOSPITAL care; OUTPATIENT medical care; ANTINEOPLASTIC agents; QUESTIONNAIRES; CANCER patients; DESCRIPTIVE statistics; TREATMENT effectiveness; LONGITUDINAL method; RESEARCH; COMPARATIVE studies; DRUGS; CONFIDENCE intervals; BRAIN tumors; MEDICAL care costs
- Publication
Cost Effectiveness & Resource Allocation, 2024, Vol 22, Issue 1, p1
- ISSN
1478-7547
- Publication type
Article
- DOI
10.1186/s12962-024-00577-6