We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical Interest in Exome-Based Analysis of Somatic Mutational Signatures for Non-Small Cell Lung Cancer.
- Authors
Peroz, Morgane; Mananet, Hugo; Roussot, Nicolas; Kaderbhai, Courèche Guillaume; Derangère, Valentin; Truntzer, Caroline; Ghiringhelli, François
- Abstract
Simple Summary: Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality. This study investigates the clinical interest of whole exome sequencing for analyzing somatic mutational signatures in patients with advanced or metastatic NSCLC treated with the current standard of care. Investigating somatic mutational signatures as well as structural variations, we evaluated the association between genomic features and patient outcomes in a cohort of 132 patients. This study identified specific signatures associated with poor response to immune checkpoint inhibitor (ICI) therapy and chemotherapy, potentially aiding treatment selection and identifying patients unlikely to benefit from these approaches. Background: Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality. This study investigates the clinical interest of whole exome sequencing (WES) for analyzing somatic mutational signatures in patients with advanced or metastatic NSCLC treated with the current standard of care. Methods: Exome sequencing data and clinical characteristics from 132 patients with advanced or metastatic NSCLC were analyzed. Somatic mutational signatures including single base substitutions (SBSs), double base substitutions (DBSs), and copy number signatures were evaluated. Structural variations including tumor mutational burden (TMB), the number of neoantigens, TCR clonality, homologous recombination deficiency (HRD), copy number alterations (CNAs), and microsatellite instability (MSI) score were determined. The association between these genomic features, NSCLC subtypes, and patient outcomes (progression-free and overall survival) was evaluated. Conclusions: Exome sequencing offers valuable insights into somatic mutational signatures in NSCLC. This study identified specific signatures associated with a poor response to immune checkpoint inhibitor (ICI) therapy and chemotherapy, potentially aiding treatment selection and identifying patients unlikely to benefit from these approaches.
- Subjects
GENOMICS; TUMOR markers; METASTASIS; IMMUNE checkpoint inhibitors; CANCER chemotherapy; LUNG tumors; LUNG cancer; GENETIC mutation; PROGRESSION-free survival; SEQUENCE analysis; GENOMES; OVERALL survival
- Publication
Cancers, 2024, Vol 16, Issue 17, p3115
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16173115