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- Title
VHH8 As a Prognostic Marker of Mortality in a Cohort of Patients with Kaposi’s Sarcoma And HIV.
- Authors
Garcia Martin, Misael Osmar; Ahumada Topete, Víctor Hugo; Castillejos López, Manuel de Jesús; Sevilla Gutiérrez, Karina Danae; Silva, Graciela Hernández; Teran, Gustavo Reyes; Ríos, Santiago Ávila; Arnoldo, Aquino Gálvez; García Navarro, Ángel Ramiro
- Abstract
Our objective was to evaluate the prognosis of the viral load (VL) of HHV8 in patients with HIV (PLHIV) and Kaposi Sarcoma (KS). In a cohort of PLHIV > 18 with KS in 4 different stages, treated with chemotherapy and molecular diagnosis for HVH8. Statistical analysis was for descriptive (frequencies and proportions or medians and interquartile ranges, as appropriate). The groups were compared with X² (qualitative variables) and Mann-Whitney U (quantitative variables). A Kaplan-Meier curve was used for survival analysis. Significance level P < 0.05. We include 82 PLHIV/SK and we select 46.7 % (56) who were positive for VHH8. Mortality was 27.7 %. Mortality (dead vs. alive) was compared according to clinical condition (stage I: 1; II: 1 vs. 5; III: 1 vs. 1; IV: 13 vs. 34) [P = 0.742]; the units for VL was copies/mL and for subgroup of lymphocytes was cel/μL. HIV VL: 114955 (1223- 347432) vs. 69677 (1745-313339) [P = 0.153]; CD4: 9.5 (9.5-42.5) vs 55 (11-151.5) [P = 0.006], CD4/CD8: 0.05 (0.02-0.09) 0.10 (0.045 -0.18) [P = 0.001]. Three groups were formed according to the VL of VHH8: > 19 to 3400, 3400.01 to 12000 and > 12000, showing differences in the survival curves [P = 0.010]. The VL of HVH8 in peripheral blood was significantly associated with the probability of mortality as a factor independent of the clinical stage of KS in PLHIV.
- Publication
Veterinaria México OA, 2024, Vol 11, p70
- ISSN
2448-6760
- Publication type
Article
- DOI
10.22201/fmvz.24486760e.2024.1305