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- Title
OP15.09: Circulating placenta‐derived extracellular vesicles contribute to endothelial dysfunction in pre‐eclampsia.
- Authors
Youssef, L.; Ramos, A.; Molina, P.; Martinez‐Sanchez, J.; Moreno‐Castaño, A.; Blasco, M.; De Moner, B.; Tortajada, M.; Camacho, M.; Borrell, M.; Crovetto, F.; Pino, M.; Escolar, G.; Carreras, E.; Gratacos, E.; Diaz‐Ricart, M.; Palomo, M.; Crispi, F.
- Abstract
This article, titled "Circulating placenta-derived extracellular vesicles contribute to endothelial dysfunction in pre-eclampsia," explores the role of placenta-derived extracellular vesicles in the development of endothelial dysfunction in pre-eclampsia. The study involved isolating these vesicles from serum samples of pre-eclampsia and normotensive pregnancies and incubating them with endothelial cells in culture. The results showed that the presence of placenta-derived extracellular vesicles led to increased expression of VCAM-1, VWF, and ROS, indicating an oxidative, prothrombotic, and proinflammatory state. This research suggests that these vesicles may play a pathogenic role in the endothelial damage associated with pre-eclampsia.
- Subjects
EXTRACELLULAR vesicles; VON Willebrand factor; ENDOTHELIUM diseases; REACTIVE oxygen species; PREECLAMPSIA
- Publication
Ultrasound in Obstetrics & Gynecology, 2024, Vol 64, p101
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.28000