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- Title
Is There a Link between Chronic Obstructive Pulmonary Disease and Lung Adenocarcinoma? A Clinico-Pathological and Molecular Study.
- Authors
Lunardi, Francesca; Nardo, Giorgia; Lazzarini, Elisabetta; Tzorakoleftheraki, Sofia-Eleni; Comacchio, Giovanni Maria; Fonzi, Eugenio; Tebaldi, Michela; Vedovelli, Luca; Pezzuto, Federica; Fortarezza, Francesco; Schiavon, Marco; Rea, Federico; Indraccolo, Stefano; Calabrese, Fiorella
- Abstract
Chronic Obstructive Pulmonary Disease (COPD) and lung cancer are strictly related. To date, it is unknown if COPD-associated cancers are different from the tumors of non-COPD patients. The main goal of the study was to compare the morphological/molecular profiles of lung adenocarcinoma (LUAD) samples of COPD, non-COPD/smokers and non-COPD/non-smokers, and to investigate if a genetic instability also characterized non-pathological areas. This study included 110 patients undergoing surgery for a LUAD, divided into three groups: COPD/smoker LUAD (38), non-COPD/smoker LUAD (54) and non-COPD/non-smoker LUAD (18). The tissue samples were systemically evaluated by pathologists and analyzed using a 30-gene Next Generation Sequencing (NGS) panel. In a subset of patients, tissues taken far from the neoplasia were also included. The non-COPD/smoker LUAD were characterized by a higher proliferative index (p = 0.001), while the non-COPD/non-smoker LUAD showed higher percentages of lepidic pattern (p = 0.008), lower necrosis, higher fibrosis, and a significantly lower mutation rate in the KRAS and PIK3CA genes. Interestingly, the same gene mutations were found in pathological and normal areas exclusively in the COPD/smokers and non-COPD/smokers. COPD/smoker LUAD seem to be similar to non-COPD/smoker LUAD, particularly for the genetic background. A less aggressive cancer phenotype was confirmed in non-COPD/non-smokers. The genetic alterations detected in normal lungs from smokers with and without COPD reinforce the importance of screening to detect early neoplastic lesions.
- Subjects
NUCLEOTIDE sequencing; OBSTRUCTIVE lung diseases; CHRONIC obstructive pulmonary disease; RAS oncogenes; LUNG cancer
- Publication
Journal of Personalized Medicine, 2024, Vol 14, Issue 8, p839
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm14080839