We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Angiogenic Factors in Endometriosis.
- Authors
TAYLOR, ROBERT N.; LEBOVIC, DAN I.; MUELLER, MICHAEL D.
- Abstract
A bstract: Similar to tumor metastases, endometriotic implants require neovascularization to establish, grow, and invade. The peritoneal environment is ideally suited to provide a proangiogenic milieu. Nevertheless, endometriotic lesions are found only in a minority of reproductive-age women (∼10%) with retrograde menstruation. In this paper, we review the major cytokines, growth factors, steroid hormones, and eicosanoids responsible for angiogenesis in endometriosis. We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 955, Issue 1, p89
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb02769.x